Galaxy is an open, web-based platform for reproducible data intensive biomedical research. It is developed and maintained jointly with James Taylor’s group at JHU and Jeremy Goecks’s lab at OHSU. Our main site performs hundreds of thousands of analyses monthly. Numerous institutions across the World run their own Galaxy instances. Members of our growing developer community from across the world contribute to Galaxy daily.
Next-Generation sequencing technologies allow detection of nucleotide changes present at very low frequencies. Unfortunately the signal is often obscured by noise. We are using cutting edge technologies such as ddPCR and duplex sequencing to overcome these challenges and understand mutational flicker. This work in performed in collaboration with Kateryna Makova at PSU.